Medizinische Klinik I: Innere Medizin - Gastroenterologie

Facharzt für Innere Medizin
Facharzt für Gastroenterologie
Diabetologe DDG

• Reviewer Award UiM/EJU 2016
• Reviewer Award Uim/EJU 2023

A. Originalarbeiten:

Erst- bzw. Letztautor:

1) T. Bernatik, D. Strobel, J. Hänsler, E.G. Hahn, D. Becker: Echosignalverstärkte Power-Doppler-Endosonographie zur Differenzierung Pankreaskarzinom vs. fokale Pankreatitis. Biomedizinische Technik 2000; 45: 546-7.  
2)T. Bernatik, D. Strobel, E.G. Hahn, D. Becker: Detection of liver metastases: comparison of contrast-enhanced wide band harmonic imaging with conventional ultrasonography. J Ultrasound Med 2001; 20: 509-15.
3) T. Bernatik, D. Strobel, E.G. Hahn, D. Becker: Lebermetastasen-Detektion - Vergleich zwischen nativem Ultraschall, „tissue harmonic imaging“ und echosignalverstärktem „wide band harmonic imaging“. Biomedizinische Technik 2001; 46: 94-5
4) T. Bernatik, D. Strobel, E.G. Hahn, D. Becker: Doppler measurements: a surrogate marker of liver fibrosis? Eur J Gastroenterol Hepatol 2002; 14: 383-7.
5) T. Bernatik, D. Strobel, J. Hänsler, E.G. Hahn, D. Becker: Hepatische Transitzeit eines Echosignalverstärkers als Indikator einer Lebermetastasierung – erste klinische Ergebnisse. Ultraschall Med 2002; 23: 91-5.
6) T. Bernatik, D. Becker, D. Neureiter, J. Hänsler, M. Frieser, S. Schaber, E.G. Hahn, D. Strobel: Lebermetastasendetektion - Vergleich Kontrastmittel-Ultraschall mit Echosignalverstärkern der ersten versus zweiten Generation. Ultraschall Med 2003; 24: 175-9.
7) T. Bernatik, D. Becker, J. Hänsler, M. Frieser, S. Schaber, A. Wein, E.G. Hahn, D. Strobel: Hepatic transit time of an echoenhancer – indicator of metastatic spread to the liver. Eur J Gastroenterol Hepatol 2004; 16: 313-17.
8) Zhou X, Strobel D, Haensler J, Bernatik T: Hepatic transit time: indicator of the therapeutic response to radiofrequency ablation of liver tumours. Br J Radiol. 2005; 78: 433-6.
9) Strobel D, Kleinecke C, Hansler J, Frieser M, Handl T, Hahn EG, Bernatik T: Contrast-enhanced sonography for the characterisation of hepatocellular carcinomas--correlation with histological differentiation. Ultraschall Med. 2005; 26: 270-6.
10) Bernatik T, Strobel D: Rationale Abklärung von fokalen Leberläsionen mittel kontrastmittelverstärktem Ultraschall. Deutsches Ärzteblatt 2006 12: 789-93.
11) Haendl T, Strobel D, Steinebrunner N, Frieser M, Hahn EG, Bernatik T: Hepatic transit time in patients with benign liver lesions. Ultraschall Med. 2008 Apr;29(2):184-9.
12) Strobel D, Seitz K, Blank W, Schuler A, Dietrich C, von Herbay A, Friedrich-Rust M, Kunze G, Becker D, Will U, Kratzer W, Albert FW, Pachmann C, Dirks K, Strunk H, Greis C, Bernatik T. Contrast-enhanced ultrasound for the characterization of focal liver lesions – diagnostic accuracy in clinical practice (DEGUM multicenter trial) Ultraschall Med 2008;29: 499-505
13) Haendl T, Strobel D, Legal W, Frieser M, Hahn EG, Bernatik T: Nierenzellkarzinome zeigen kein typisches Perfusionsverhalten in der Kontrastmittelsonographie. Ultraschall Med 2009;30: 58-63
14) Frieser M, Lindner A, Meyer S, Westerteicher M, Hänsler J, Haendl T, Hahn EG, Strobel D, Bernatik T: Spektrum und Blutungskomplikationen sonographisch gesteuerter Interventionen an Leber und Pankreas. Ultraschall Med 2009; 30:168-74.
15) Strobel D, Blank W, Schuler A, Dietrich CF, von Herbay A, Friedrich-Rust M, Bernatik T.: Tumor specific vascularization pattern of liver metastases,  hepatocellular  carcinoma, hemangioma and focal nodular hyperplasia in the differential diagnosis  of 1349 liver lesions in contrast enhanced ultrasound. Ultraschall in Med 2009; 30: 376-82
16) Bernatik T, Seitz KH, Blank W, Schuler A, Dietrich CF, Strobel D. Unclear focal liver lesions in contrast-enhanced ultrasonography – lessons to be learned from the DEGUM multicenter study for the characterization of focal liver lesions. Ultraschall in Med 2010; 31: 577-81.
17) Haendl T, Strobel D, Neureiter D, Esser K, Frieser M, Hahn EG, Bernatik T: Hepatische Transitzeit als Indikator einer Lebermetastasierung – Vergleich der aktuell verfügbaren US-Kontrastmittel. Ultraschall Med. 2010 Dec;31(6):582-8
18) Strobel D, Goertz RS, Bernatik T. Diagnostics in inflammatory bowel disease. World J Gastroenterol. 2011 Jul 21:17(27):3192-7.
19) Bernatik T, Schuler A, Kunze G, Mauch M, Dietric CF, Dirks K, Pachmann C, Börner N, Fellermann K, Menzel J, Strobel D: Benefit of Contrast-enhanced Ultrasound (CEUS) in the Follow-Up Care of Patients with Colon Cancer: a prospective multicenter study. Ultraschall Med. 2015 Dec;36(6):590-3.
20) Bernatik T: Congress report of the US-DLT 2017 – summary. Ultraschall Med. 2018 Oct;39(5):562-3.
21) Bernatik T: Congress report of the US-DLT 2018 – summary. Ultraschall Med. 2019 Oct;40(5):655-6.

Co-Autor:

1) D. Becker, D. Strobel, T. Bernatik, E.G. Hahn: Echo-enhanced color- and power-Doppler EUS for the discrimination between focal pancreatitis and pancreatic carcinoma. Gastrointest Endosc 2001; 53: 784-9.
2) D. Becker, T. Bernatik, D. Strobel, J. Hänsler, E.G. Hahn: Transitzeit von Echosignalverstärkern in der Leber bei Lebergesunden und Patienten mit Leberzirrhose. Biomedizinische Technik 2001; 46: 78-9.
3) J. Hänsler, D. Neureiter, T. Bernatik, M. Zürl, D. Strobel, T. Schneider, W. Müller, E.G. Hahn, D. Becker: Hochfrequenzinduzierte Thermotherapie (HiTT) mit perfundierten Nadelapplikatoren – Untersuchungen am VX2-Tumormodell des Kaninchens – erste Ergebnisse. Biomedizinische Technik 2001; 45: 90-1.
4) A. Wein, C. Riedel, F. Kockerling, P. Martus, U. Baum, W.M. Brueckl, T. reck, R. Ott, J. Hänsler, T. Bernatik, D. Becker, T. Schneider, W. Hohenberger, E.G. Hahn: Impact of surgery on survival in palliative patients with metastatic colorectal cancer after first line treatment with weekly 24-hour infusion of high-dose 5-fluorouracil and folinic acid. Ann Oncol 2001; 12: 1721-7.
5) J. Hänsler, D. Neureiter, D. Strobel, W. Müller, D. Mutter, T. Bernatik, E.G. Hahn, D. Becker: Cellular and vascular reactions in the liver to radio-frequency thermoablation with wet-needle applicators. Eur Surg Res 2002; 34: 357-63.
6) J. Hänsler, A. Witte, D. Strobel, A. Wein, T. Bernatik, M. Pavel, W. Müller, E.G. Hahn, D. Becker: Hochfrequenzthermotherapie mit perfundierten Nadelapplikatoren bei der Behandlung primärer und sekundärer Lebertumore. Ultraschall Med 2003; 24: 27-33.
7) J. Hänsler, M. Frieser, S. Schaber, C Kutschall, T. Bernatik, W. Müller, D. Becker, E.G. Hahn, D. Strobel: Radiofrequency ablation of hepatocellular carcinoma with saline solution perfusion device. JVIR 2003; 14: 575-80.
8) J. Hänsler, D. Neureiter, M. Wasserburger, R. Janka, T. Bernatik, T. Schneider, W. Müller, M. Frieser, S. Schaber, D. Becker, E.G. Hahn, D. Strobel: Percutaneous US-guided radiofrequency ablation with perfused needle applicators: improved survival with the VX2 tumor model in rabbits. Radiology 2004; 230: 169-174.
9) M. Frieser, J. Haensler, S. Schaber, A. Peters, E. Mohelsky, T. Bernatik, E.G. Hahn, D. Strobel: Radiofrequency ablation of liver tumors: how to enlarge the necrotic zones? Eur Surg Res 2004; 36: 357-61.
10) Frieser M, Haensler J, Schaber S, Peters A, Mohelsky E, Bernatik T, Hahn EG, Strobel D: Radiofrequency ablation of liver tumors: how to enlarge the necrotic zones? Eur Surg Res. 2004; 36: 357-61.
11) Frieser M, Schaber S, Peters A, Bernatik T, Haendl T, Hahn EG, Strobel D, Haensler J: Radiofrequency ablation using perfused needle electrodes – study of intermittent and continuous triple needle application ex vivo. Eur Surg Res 2005; 37: 312-6. 
12) Maiss J, Baumbach C, Zopf Y, Naegel A, Wehler M, Bernatik T, Hahn EG, Schwab D: Hemodynamic efficacy of the new resolution clip device in comparison with high-volume injection therapy in spurting bleeding: a prospective experimental trial using the compactEASIE simulator. Endoscopy. 2006; 38: 808-12. 
13) Hansler J, Wissniowski TT, Schuppan D, Witte A, Bernatik T, Hahn EG, Strobel D: Activation and dramatically increased cytolytic activity of tumor specific T-lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases. World J Gastroenterol. 2006 12: 3716-21. 
14) Hansler J, Frieser M, Tietz V, Uhlke D, Wissniowski T, Bernatik T, Hothorn T, Hahn EG, D. Strobel: Percutaneous radiofrequency ablation of liver tumors  using multiple saline-perfused electrodes. J Vasc Interv Radiol. 2007; 18: 405-10.
15) Frieser M, Schaber S, Strobel D, Bernatik T, Wehr H, Peters A, Hahn EG, Haensler J. Prolonged survival through combined treatment with radiofrequency ablation/ethanol instillation compared with radiofrequency ablation alone in the VX2 rabbit liver tumour model. Ultraschall Med. 2007 Apr;28(2):176-80.
16) Hänsler J, Frieser M, Tietz V, Uhlke D, Wissniowski TT, Bernatik T, Hahn EG, Strobel D. Percutaneous ultrasound-guided radiofrequency ablation (RFA) using saline-perfused (wet) needle electrodes for the treatment of hepatocellular carcinoma--long term experience Ultraschall Med. 2007 Dec;28(6):604-11
17) Frieser M, Schaber S, Strobel D, Bernatik T, Wehr H, Peters A, Hahn EG, Haensler J: Überlebensvorteil durch Kombinationsbehandlung mit Radiofrequenzablation/Alkoholinstillation im Vergleich zur alleinigen Radiofrequenzablation im VX2 Lebertumormodell am Kaninchen. Ultraschall Med. 2007 Apr;28(2):176-80
18) Seitz KH, Strobel D, Bernatik T, Blank W, friedrich-Rust M, Herbay A, Dietrich CF, Strunk H, Kratzer W, Schuler A: Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions – prospective comparison in clinical practice: CEUS vs. CT. Ultraschall Med 2009; 30: 383-9
19) Görtz R, Bernatik T, Strobel D, Hahn EG, Händl T: Sofware-based quantification of contrast-enhanced ultrasound in focal liver lesions - a feasibility study. Eur J Radiol. 2010 Aug;75(2): 22-6
20) Frieser M, Strobel D, Schaber S, Wissniowski TT, Bernatik T, Adis S, Hahn EG, Hänsler JM: Pulsed radiofrequency ablation using perfused needle applicators in an in vitro trial on bovine liver. Biomed Tech 2010 Apr;55(2):101-7. 
21) Goertz RS, Zopf Y, Jugl V, Heide R, Janson C, Strobel D, Bernatik T, Haendl T: Measurement of liver elasticity with acoustic radiation force impulse (ARFI) technology: an alternative noninvasive method for staging liver fibrosis in viral hepatitis. Ultraschall Med. 2010 Apr;31(2):151-5.
22) Heide R, Strobel D, Bernatik T, Goertz RS: Characterization of focal liver lesions (FLL) with acoustic radiation force impulse (ARFI) elastometry. Ultraschall Med. 2010 Aug;31(4):405-9.
23) Seitz K, Bernatik T, Strobel D, Blank W, Friedrich-Rust M, Strunk H, Greis C, Kratzer W, Schuler A: Contrast-enhanced ultrasound (CEUS) for the characterization of focal liver lesions in clinical practice (DEGUM Multicenter Trial): CEUS vs. MRI--a prospective comparison in 269 patients. Ultraschall Med. 2010 Oct;31(5):492-9
24) Goertz RS, Amann K, Heide R, Bernatik T, Neurath MF, Strobel D: An abdominal and thyroid status with Acoustic Radiation Force Impulse Elastometry - A feasibility study Acoustic Radiation Force Impulse Elastometry of human organsEur J Radiol. 2010 Oct 22.
25) Ende A, Zopf Y, Heide R, Bernatik T, Wehler M, Schwab D, Hahn EG, Maiss J: Hemodynamic efficacy of sequential hemoclip application using the Olympus HX-110/610 reloadable clipping device in spurting bleedings. Med Sci Monit. 2011 Jan;17(1): MT1-6.
26) Frieser M, Kiesel J, Lindner A, Bernatik T, Haensler JM, Janka R, Hahn EG, Strobel D: Efficacy of contrast-enhanced US versus CT or MRI for the therapeutic control of percutaneous radiofrequency ablation in the case of hepatic malignancies. Ultraschall Med. 2011 Apr;32(2):148-53.
27) Neumann H, Vieth M, Siebler J, Bernatik T, Neurath MF, Boxberger F: Fluorescein-aided endomicroscopy for detection of signet ring cell carcinomaEndoscopy. 2011; 43 Suppl 2: E199-200. 
28) Neumann H, Nägel A, Bernatik T, Wickles N, Neurath MF, Raithel M: Endoscopic closure of large, spontaneous, choledochoduodenal fistula by using an over-the-scope clip. Gastrointest Endosc. 2011 Jul;74(1):200-2.
29) Greten TF et al.: Diagnose und Therapie des Hepatocellulären Karzinoms: Z Gastroenterol 2013 Nov;51(11):1269-326.
30) Neumann H, Vieth M, Atreya R, Grauer M, Siebler J, Bernatik T, Neurath MF, Mudter J: Assesment of Crohn´s disease activity by confocal laser endomicroscopy. Inflamm Bowel Dis. 2012 Dec;18(12):2261-9.
31) Neumann H, Vieth M, Atreya R, Bernatik T, Mudter J, Neurath MF: Inverted diverticulum or adenomatous lesion? Identification using confocal laser endomicroscopy. Gastrointest Endosc. 2012 May;75(5):1102. 
32) Knieling F, Waldner MJ, Goerzt RS, Zopf S, Wildner D, Neurath MF, Bernatik T, Strobel D: Early response to anti-tumoral treatment in hepatocellular carcinoma – can quantitative contrast-enhanced ultrasound predict outcome? Ultraschall Med. 2013 Feb;354(1):38-46.
33) Lindner A, Frieser M, Heide R, Wildner D, Neurath MF, Dauth W, Bernatik T, Strobel D: postinterventional pain and complications of sonographically guided interventions in the liver and pancreas. Ultraschall Med. 2014 Apr;35(2):159-65.
34) Wildner D, Pfeifer L, Goertz RS, Bernatik T, Sturm J, Neurath MF, Strobel D: Dynamic contrast-enhanced ultrasound (DCE-US) fort he characterization of hepatocellular carcinoma and cholangiocellular carcinoma. Ultraschall Med. 2014 Dec;35(6):522-57. 
35) Wildner D, Bernatik T, Greis C, Seitz K, Neurath MF, Strobel D: CEUS in hepatocellular carcinoma and intrahepatic cholangiocellular carcinoma in 320 patients – early or late washout matters. Ultraschall Med. 2015 Apr;36(2):132-9.
36) Strobel D, Bernatik T et al.: Incidence of bleeding in 8172 percutaneous ultrasound-guided intraabdominal diagnostic and therapeutic interventions – results of the prospective multicenter DEGUM interventional ultrasound study. Ultraschall Med. 2015 Apr;36(2):122-31. 
37) Vitali F, Strobel D, Frulloni L, Heinrich M, Pfeifer L, Goerzt RS, Hundorfean G, Wachter DL, Gruetzmann R, Bernatik T, Neurath MF, Wildner D: The importance of pancreatic inflammation in endosonographic diagnostics of solid pancreatic masses. Med Ultrason. 2018 Dec 8;20(4):427-35. 
38) Schellhaas B, Bernatik T et al.: Contrast-Enhaced Ultrasound Algorithms (CEUS-LIRADS/ESCULAP) for the Noninvasive Diagnosis of Hepatocellular Carcinoma – a prospective multicenter DEGUM Study. Ultraschall Med. 2020 Jul;14
39) Schellhaas B, Bernatik T et al.: Contrast-Enhanced Ultrasound Algorithms (CEUS-LIRADS/ESCULAP) for the Noninvasive Diagnosis of Hepatocellular Carcinoma - A Prospective Multicenter DEGUM Study. Ultraschall Med 2021 Apr; 48: 178-86. 
40) Schellhaas B, Bernatik T. et al.: Contrast-Enhanced Ultrasound Patterns fort he Non-invasive Diagnosis of Hepatocellular Carcinoma: A Prospective Multicenter Study in Histologically Proven Liver Lesions in a Real-Life Setting Demonstrating the Benefit of Extended Late Phase Observation. Ultraschall Med 2021 Nov; 47: 3170-80.
41) Roeb E et al.: Aktualisierte S2k-Leitlinie nicht-alkoholische Fettlebererkrankung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) Z Gastroenterol. 2022 Sep;60(9):1346-1421.

Deutsche Gesellschaft für Verdauungs. und Stoffwechselerkrankungen (DGVS)
Deutsche Gesellschaft für Ultraschall in der Medizin (DEGUM)
Deutsche Diabetes Gesellschaft (DDG)

Studien im Bereich Onkologie, Hepatologie, Pankreatologie
Mitarbeit bei Leitlinienerstellung: HCC, MASLD